{"id":14821,"date":"2025-12-06T19:38:01","date_gmt":"2025-12-06T17:38:01","guid":{"rendered":"https:\/\/biology.upatras.gr\/personel\/leontiadis\/"},"modified":"2025-12-06T19:47:27","modified_gmt":"2025-12-06T17:47:27","slug":"leontiadis","status":"publish","type":"avada_portfolio","link":"https:\/\/biology.upatras.gr\/en\/personel\/leontiadis\/","title":{"rendered":"Leonidas J. Leontiadis"},"content":{"rendered":"

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Faculty Staff \/ Section of Animal Biology
\n<\/strong>Assistant Professor of Physiology \/ Neurobiology
\n<\/strong>Office location<\/strong>: 3rd<\/sup> Floor, B\/M 310.2
\nEmail<\/strong>: ljleontas@upatras.gr
\nTelephone<\/strong>: +30 2610 962395<\/p>\n<\/div>

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\"\"Curriculum Vitae<\/a>
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Education<\/h2>\n
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  • BSc in Biology (2001), Biology Department, University of Patras<\/li>\n
  • PhD in Biological Sciences (2012), Department of Biology, National and Kapodistrian University of Athens<\/li>\n<\/ul>\n<\/div>\n
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    Educational activities<\/h2>\n
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    Undergraduate Courses:<\/strong><\/p>\n

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    • Animal Physiology<\/li>\n
    • Brain and Mind<\/li>\n
    • Experimental Animal Physiology<\/li>\n<\/ul>\n

      Postgraduate Courses:<\/strong><\/p>\n

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      • Research Methodology (Postgraduate Programme \u201cBiological Technology: Research and Applications\u201d, Biology Department)<\/li>\n
      • Cutting-edge Topics in Neurobiology and Regenerative Biology (Postgraduate Programme \u201cBiological Technology: Research and Applications\u201d, Biology Department)<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
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        Research and other activities<\/h2>\n
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        General description<\/strong><\/p>\n

        Neurophysiology, Neurobiology. Systems and mechanisms of synaptic transmission and plasticity. Spontaneous and evoked activity of neural networks, mechanisms of memory and learning. Study of physiological and pathophysiological conditions using animal models (fragile X syndrome, autism, epilepsy). Role of neuromodulatory systems (cannabinoids, opioids), pharmacology and cellular signaling of neuronal receptors.<\/p>\n

        Specific studies<\/strong><\/p>\n

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        • Study of the physiology of neural networks and the state of excitation\/inhibition balance in the hippocampus of a rat animal model of Fragile X Syndrome and Autism<\/li>\n
        • Investigation of the endocannabinoid system and the action of cannabinoid substances on the function of neurons and networks in the hippocampus. Effect of cannabinoids on memory\/learning mechanisms in a normal animal model as well as in the Fragile X Syndrome model<\/li>\n
        • Correlation of the action of the opioid system with long-term potentiation (LTP) and cellular autophagy in mouse animal models<\/li>\n
        • Study of the differentiation of spontaneous and evoked activity and the channels that influence them along the hippocampus<\/li>\n
        • Study of spontaneous activity in the neocortex and the effect of early developmental seizures on this activity<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
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          Representative Publications<\/h2>\n
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          • Tsotsokou G., Miliou A., Trompoukis G., Leontiadis L.J.<\/strong>, Papatheodoropoulos C. (2024). \u201cRegion-Related Differences in Short-Term Synaptic Plasticity and Synaptotagmin-7 in the Male and Female Hippocampus of a Rat Model of Fragile X Syndrome\u201d. International Journal Molecular Sciences,<\/em> 25(13): 6975. DOI: 10.3390\/ijms25136975<\/li>\n
          • Leontiadis L.J.<\/strong>, Felemegkas P., Trompoukis G., Tsotsokou G., Miliou A., Karagianni E., Rigas P., Papatheodoropoulos C. (2024). \u201cSeptotemporal variation of information processing in the hippocampus of Fmr1 KO rat\u201d. Developmental Neuroscience,<\/em> 46(6): 353-364. DOI: 10.1159\/000537879<\/li>\n
          • Ntoulas G., Brakatselos C., Nakas G., Asprogerakas M.Z., Delis F., Leontiadis L.J.<\/strong>, Trompoukis G., Papatheodoropoulos C., Gkikas D., Valakos D., Vatsellas G., Politis P.K., Polissidis A., Antoniou K. (2024). \u201cMulti-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function\u201d. Translational Psychiatry,<\/em> 14(1): 104. DOI: 10.1038\/s41398-024-02815-0<\/li>\n
          • Leontiadis L.J.<\/strong>, Trompoukis G., Tsotsokou G., Miliou A., Felemegkas P., Papatheodoropoulos C. (2023). \u201cRescue of sharp wave-ripples and prevention of network hyperexcitability in the ventral but not the dorsal hippocampus of a rat model of fragile X syndrome\u201d. Frontiers in Cellular Neuroscience,<\/em> 17: 1296235. DOI: 10.3389\/fncel.2023.1296235<\/li>\n
          • Leontiadis L.J.<\/strong>, Trompoukis G., Felemegkas P., Tsotsokou G., Miliou A., Papatheodoropoulos C. (2023). \u201cIncreased Inhibition May Contribute to Maintaining Normal Network Function in the Ventral Hippocampus of a Fmr1-Targeted Transgenic Rat Model of Fragile X Syndrome\u201d. Brain Sciences,<\/em> 13(11): 1598. DOI: 10.3390\/brainsci13111598<\/li>\n
          • Trompoukis G., Leontiadis L.J.<\/strong>, Rigas P., Papatheodoropoulos C. (2021). \u201cScaling of network excitability and inhibition may contribute to the septotemporal differentiation of sharp waves-ripples in rat hippocampus in vitro\u201d. Neuroscience<\/em>, 458: 11-30. DOI: 10.1016\/j.neuroscience.2020.12.033<\/li>\n
          • Trompoukis G., Rigas P., Leontiadis L.J.<\/strong>, Papatheodoropoulos C. (2020). \u201cIh, GIRK, and KCNQ\/Kv7 channels differently modulate sharp wave – ripples in the dorsal and ventral hippocampus\u201d. Molecular and Cellular Neurosciences<\/em>, 107: 103531. DOI: 10.1016\/j.mcn.2020.103531<\/li>\n
          • Rigas P., Sigalas C., Nikita M., Kaplanian A., Armaos K., Leontiadis L.J.<\/strong>, Zlatanos C., Kapogiannatou A., Peta C., Katri A., Skaliora I. (2018). \u201cLong-Term Effects of Early Life Seizures on Endogenous Local Network Activity of the Mouse Neocortex\u201d. Frontiers in Synaptic Neuroscience<\/em>, 10: 43. DOI: 10.3389\/fnsyn.2018.00043<\/li>\n
          • Rigas P., Leontiadis L.J.<\/strong>, Tsakanikas P., Skaliora I. (2017). \u201cSpontaneous neuronal network persistent activity in the neocortex: a(n) (endo)phenotype of brain (patho)physiology\u201c. Advances in Experimental Medicine and Biology<\/em>, 988: 235-247. DOI: 10.1007\/978-3-319-56246-9_19<\/li>\n
          • Leontiadis L.J.<\/strong>, Papakonstantinou M.-P., Georgoussi Z. (2009). \u201cRegulator of G protein signaling 4 confers selectivity to specific G proteins to modulate mu- and delta-opioid receptor signaling\u201d. Cellular Signalling<\/em>, 21(7): 1218-28. DOI: 10.1016\/j.cellsig.2009.03.013<\/li>\n
          • Georgoussi Z., Leontiadis L.<\/strong>, Mazarakou G., Merkouris M., Hyde K., Hamm H. (2006). \u201cSelective interactions between G protein subunits and RGS4 with the C-terminal domains of the mu- and delta-opioid receptors regulate opioid receptor signaling\u201d. Cellular Signalling, 18(6): 771-82. DOI: 10.1016\/j.cellsig.2005.07.003<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>
            <\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"

            Assistant Professor | ljleontas@upatras.gr | +30 2610 962395<\/p>\n","protected":false},"author":213,"featured_media":14822,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"portfolio_category":[158,151],"portfolio_skills":[157],"portfolio_tags":[],"class_list":["post-14821","avada_portfolio","type-avada_portfolio","status-publish","format-standard","has-post-thumbnail","hentry","portfolio_category-assistant-professor","portfolio_category-section-of-animal-biology","portfolio_skills-assistant-professor"],"_links":{"self":[{"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/avada_portfolio\/14821","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/avada_portfolio"}],"about":[{"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/types\/avada_portfolio"}],"author":[{"embeddable":true,"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/users\/213"}],"replies":[{"embeddable":true,"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/comments?post=14821"}],"version-history":[{"count":3,"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/avada_portfolio\/14821\/revisions"}],"predecessor-version":[{"id":14825,"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/avada_portfolio\/14821\/revisions\/14825"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/media\/14822"}],"wp:attachment":[{"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/media?parent=14821"}],"wp:term":[{"taxonomy":"portfolio_category","embeddable":true,"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/portfolio_category?post=14821"},{"taxonomy":"portfolio_skills","embeddable":true,"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/portfolio_skills?post=14821"},{"taxonomy":"portfolio_tags","embeddable":true,"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/portfolio_tags?post=14821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}