{"id":15131,"date":"2026-02-10T17:51:53","date_gmt":"2026-02-10T15:51:53","guid":{"rendered":"https:\/\/biology.upatras.gr\/personel\/borbolis\/"},"modified":"2026-02-12T21:28:25","modified_gmt":"2026-02-12T19:28:25","slug":"borbolis","status":"publish","type":"avada_portfolio","link":"https:\/\/biology.upatras.gr\/en\/personel\/borbolis\/","title":{"rendered":"Borbolis Karolos-Fivos"},"content":{"rendered":"

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Faculty Staff \/ Section of Genetics, Cell & Developmental Biology
\n<\/strong>Assistant Professor
\n<\/strong>Office location: <\/strong>2nd Floor (\u0392\/\u039c 284.3)
\n<\/strong>Email: <\/strong>fborbolis@upatras.gr
\n<\/strong>Telephone: <\/strong>+30 2610 997275<\/p>\n<\/div>

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\"\"<\/a> Curriculum<\/b>\u00a0vitae<\/a><\/strong><\/p>\n<\/div>

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Education<\/h2>\n
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  • BSc in Biology: Department of Biology, National and Kapodistrian University of Athens (2009)<\/li>\n
  • MSc in Molecular Medicine: Medical School, National and Kapodistrian University of Athens (2012)<\/li>\n
  • PhD: Department of Biology, National and Kapodistrian University of Athens (2017)<\/li>\n
  • Post-doctoral research: Laboratory of Molecular Genetics of Aging, Biomedical Research Foundation of the Academy of Athens (2017-2021)<\/li>\n
  • Post-doctoral research: Department of Biology, University of Padova (2022-2023)<\/li>\n
  • Post-doctoral research: Unit of Neurogenetics and Aging, Laboratory of Physiology, Medical School, National and Kapodistrian University of Athens (2025-2025)<\/li>\n<\/ul>\n

    Educational activities<\/h2>\n

    Undergraduate courses:<\/p>\n

      \n
    • Molecular Biology<\/li>\n
    • Molecular Biotechnology<\/li>\n<\/ul>\n

      Research and other activities<\/h2>\n

      Study of fundamental molecular and cellular mechanisms involved in aging, age\u2011associated diseases, and in the adaptation of cells and organisms to stress or disease.<\/p>\n

      Development and application of various Caenorhabditis elegans<\/em> strains and genetic tools\u2014including genetic and functional models of human diseases\u2014for the investigation of conserved biological mechanisms at the organismal level.<\/p>\n

      Main research directions:<\/p>\n

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      • Post\u2011transcriptional regulation of gene expression, with emphasis on mRNA metabolism and its role in aging and age\u2011related pathologies<\/li>\n
      • Mitochondrial function and dysfunction in pathological conditions, with emphasis on neurodegeneration<\/li>\n
      • Interconnection between mitochondrial biology, lipid metabolism, and mechanisms for the maintenance of genome integrity<\/li>\n<\/ul>\n

        Representative Publications<\/h2>\n
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        • Roussos A*, Kitopoulou K*,\u00a0Borbolis F*<\/b>, Ploumi C*, Gianniou DD, Li Z, He H, Tsakiri E, Borland H, Kostakis IK, Samiotaki M, Trougakos IP., Bohr VA, Palikaras K (2025). Urolithin \u0391 modulates inter-organellar communication via calcium-dependent mitophagy to promote healthy ageing.\u00a0Autophagy.<\/b>\u00a02025 Dec;21(12):3097-3122.\u00a0<\/span>*Equal contribution<\/span><\/li>\n
        • Borbolis F*<\/strong>, Ploumi C*, Palikaras K (2024). Calcium-mediated regulation of mitophagy: Implications in neurodegenerative diseases. NPJ Metab Health Dis, 2025;3(1):4. *Equal contribution<\/li>\n
        • Tiwari V, Buvarp E, Borbolis F<\/strong>, Puligilla C, Croteau DL, Palikaras K, Bohr VA (2024). Loss of DNA glycosylases improves health and cognitive function in a elegans<\/em> model of human tauopathy. Nucleic Acids Res., 2024 Aug 16:gkae705.<\/li>\n
        • Borbolis F<\/strong> and Palikaras K (2024). Identifying therapeutic compounds for Autosomal Dominant Optic Atrophy (ADOA) through screening in the nematode elegans<\/em>. Methods Cell Biol. 2024:188:89-108.<\/li>\n
        • Roussos A*<\/sup>, Kitopoulou K*<\/sup>, Borbolis F<\/strong>, Palikaras K (2023). Caenorhabditis elegans<\/em> as a Model System to Study Human Neurodegenerative Disorders. Biomolecules. 2023 Mar 5;13(3):478. *Equal contribution<\/li>\n
        • Borbolis F<\/strong>, Ranti D, Papadopoulou MD, Dimopoulou S, Malatras A, Michalopoulos I, Syntichaki P (2023). Selective destabilization of transcripts by mRNA decapping regulates oocyte maturation and innate immunity gene expression during ageing in elegans<\/em>. Biology (Basel). 2023 Jan 21;12(2):171<\/li>\n
        • Borbolis F<\/strong> and Palikaras K (2022). The compartmentalized nature of neuronal mitophagy: molecular insights and implications. Expert Reviews in Molecular Medicine, 2022 Sep 29:24:e38.<\/li>\n
        • Borbolis F<\/strong> and Syntichaki P (2021). Biological implications of decapping: beyond bulk mRNA decay. FEBS Journal 2021.<\/li>\n
        • Borbolis F<\/strong>, Rallis J, Kanatouris G, Kokla N, Karamalegkos A, Vasileiou C, Vakaloglou KM, Diallinas G, Stravopodis DJ, Zervas CG, Syntichaki P (2020). mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageing. eLife 2020 Vol. 9.<\/li>\n
        • Borbolis F<\/strong>, Flessa C M, Roumelioti F, Diallinas G, Stravopodis D J, Syntichaki P (2017). Neuronal function of the mRNA decapping complex determines survival of Caenorhabditis elegans<\/em> at high temperature through temporal regulation of heterochronic gene expression. Open Biology 2017 Vol. 7(3).<\/li>\n
        • Rousakis A, Vlanti A, Borbolis F<\/strong>, Roumelioti F, Kapetanou M, Syntichaki P (2014). Diverse Functions of mRNA Metabolism Factors in Stress Defense and Aging of Caenorhabditis elegans<\/em>. Plos|One 2014 Vol. 9(7) p. e103365.<\/li>\n<\/ul>\n<\/div>
          <\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"

          Assistant Professor | fborbolis@upatras.gr | +30 2610 997275<\/p>\n","protected":false},"author":213,"featured_media":15132,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"portfolio_category":[158,124],"portfolio_skills":[157,168],"portfolio_tags":[],"class_list":["post-15131","avada_portfolio","type-avada_portfolio","status-publish","format-standard","has-post-thumbnail","hentry","portfolio_category-assistant-professor","portfolio_category-department-of-genetic-cell-biology-evolution","portfolio_skills-assistant-professor","portfolio_skills-epikoyros-kathigitis-en"],"_links":{"self":[{"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/avada_portfolio\/15131","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/avada_portfolio"}],"about":[{"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/types\/avada_portfolio"}],"author":[{"embeddable":true,"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/users\/213"}],"replies":[{"embeddable":true,"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/comments?post=15131"}],"version-history":[{"count":7,"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/avada_portfolio\/15131\/revisions"}],"predecessor-version":[{"id":15164,"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/avada_portfolio\/15131\/revisions\/15164"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/media\/15132"}],"wp:attachment":[{"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/media?parent=15131"}],"wp:term":[{"taxonomy":"portfolio_category","embeddable":true,"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/portfolio_category?post=15131"},{"taxonomy":"portfolio_skills","embeddable":true,"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/portfolio_skills?post=15131"},{"taxonomy":"portfolio_tags","embeddable":true,"href":"https:\/\/biology.upatras.gr\/en\/wp-json\/wp\/v2\/portfolio_tags?post=15131"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}