Leonidas J. Leontiadis

Undergraduate Courses:

• Animal Physiology
• Brain and Mind
• Experimental Animal Physiology

Postgraduate Courses:

• Research Methodology (Postgraduate Programme “Biological Technology: Research and Applications”, Biology Department)
• Cutting-edge Topics in Neurobiology and Regenerative Biology (Postgraduate Programme “Biological Technology: Research and Applications”, Biology Department)

General description

Neurophysiology, Neurobiology. Systems and mechanisms of synaptic transmission and plasticity. Spontaneous and evoked activity of neural networks, mechanisms of memory and learning. Study of physiological and pathophysiological conditions using animal models (fragile X syndrome, autism, epilepsy). Role of neuromodulatory systems (cannabinoids, opioids), pharmacology and cellular signaling of neuronal receptors.

Specific studies

• Study of the physiology of neural networks and the state of excitation/inhibition balance in the hippocampus of a rat animal model of Fragile X Syndrome and Autism
• Investigation of the endocannabinoid system and the action of cannabinoid substances on the function of neurons and networks in the hippocampus. Effect of cannabinoids on memory/learning mechanisms in a normal animal model as well as in the Fragile X Syndrome model
• Correlation of the action of the opioid system with long-term potentiation (LTP) and cellular autophagy in mouse animal models
• Study of the differentiation of spontaneous and evoked activity and the channels that influence them along the hippocampus
• Study of spontaneous activity in the neocortex and the effect of early developmental seizures on this activity

• Tsotsokou G., Miliou A., Trompoukis G., Leontiadis L.J., Papatheodoropoulos C. (2024). “Region-Related Differences in Short-Term Synaptic Plasticity and Synaptotagmin-7 in the Male and Female Hippocampus of a Rat Model of Fragile X Syndrome”. International Journal Molecular Sciences, 25(13): 6975. DOI: 10.3390/ijms25136975
• Leontiadis L.J., Felemegkas P., Trompoukis G., Tsotsokou G., Miliou A., Karagianni E., Rigas P., Papatheodoropoulos C. (2024). “Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat”. Developmental Neuroscience, 46(6): 353-364. DOI: 10.1159/000537879
• Ntoulas G., Brakatselos C., Nakas G., Asprogerakas M.Z., Delis F., Leontiadis L.J., Trompoukis G., Papatheodoropoulos C., Gkikas D., Valakos D., Vatsellas G., Politis P.K., Polissidis A., Antoniou K. (2024). “Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function”. Translational Psychiatry, 14(1): 104. DOI: 10.1038/s41398-024-02815-0
• Leontiadis L.J., Trompoukis G., Tsotsokou G., Miliou A., Felemegkas P., Papatheodoropoulos C. (2023). “Rescue of sharp wave-ripples and prevention of network hyperexcitability in the ventral but not the dorsal hippocampus of a rat model of fragile X syndrome”. Frontiers in Cellular Neuroscience, 17: 1296235. DOI: 10.3389/fncel.2023.1296235
• Leontiadis L.J., Trompoukis G., Felemegkas P., Tsotsokou G., Miliou A., Papatheodoropoulos C. (2023). “Increased Inhibition May Contribute to Maintaining Normal Network Function in the Ventral Hippocampus of a Fmr1-Targeted Transgenic Rat Model of Fragile X Syndrome”. Brain Sciences, 13(11): 1598. DOI: 10.3390/brainsci13111598
• Trompoukis G., Leontiadis L.J., Rigas P., Papatheodoropoulos C. (2021). “Scaling of network excitability and inhibition may contribute to the septotemporal differentiation of sharp waves-ripples in rat hippocampus in vitro”. Neuroscience, 458: 11-30. DOI: 10.1016/j.neuroscience.2020.12.033
• Trompoukis G., Rigas P., Leontiadis L.J., Papatheodoropoulos C. (2020). “Ih, GIRK, and KCNQ/Kv7 channels differently modulate sharp wave – ripples in the dorsal and ventral hippocampus”. Molecular and Cellular Neurosciences, 107: 103531. DOI: 10.1016/j.mcn.2020.103531
• Rigas P., Sigalas C., Nikita M., Kaplanian A., Armaos K., Leontiadis L.J., Zlatanos C., Kapogiannatou A., Peta C., Katri A., Skaliora I. (2018). “Long-Term Effects of Early Life Seizures on Endogenous Local Network Activity of the Mouse Neocortex”. Frontiers in Synaptic Neuroscience, 10: 43. DOI: 10.3389/fnsyn.2018.00043
• Rigas P., Leontiadis L.J., Tsakanikas P., Skaliora I. (2017). “Spontaneous neuronal network persistent activity in the neocortex: a(n) (endo)phenotype of brain (patho)physiology“. Advances in Experimental Medicine and Biology, 988: 235-247. DOI: 10.1007/978-3-319-56246-9_19
• Leontiadis L.J., Papakonstantinou M.-P., Georgoussi Z. (2009). “Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate mu- and delta-opioid receptor signaling”. Cellular Signalling, 21(7): 1218-28. DOI: 10.1016/j.cellsig.2009.03.013
• Georgoussi Z., Leontiadis L., Mazarakou G., Merkouris M., Hyde K., Hamm H. (2006). “Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the mu- and delta-opioid receptors regulate opioid receptor signaling”. Cellular Signalling, 18(6): 771-82. DOI: 10.1016/j.cellsig.2005.07.003